GPX1 and diabetes mellitus: In one study, GPx activity and expression, especially GPx1 (an important kidney GPx subunit) have been increased after induction of DM, but after DM progression its activity was diminished (de Haan, Stefanovic, Nikolic-Paterson, Scurr, Croft, Mori, Hertzog, Kola, Atkins and Tesch 2005 ▶).