HABP2 and cancer: These data add further support to observations that HABP2 gene expression is dysregulated in various cancers, as recently suggested.52 However, similar to the HABP2 siRNA knockdown experiments, overexpression of the rs7080536 allele also increased colony formation, suggesting that rs7080536 is a loss-of-function allele as previously reported53 and not as a dominantly inherited gain-of-function allele.