Similarly, the AF for HABP2 rs7080536 is 3.8% in the Exome Variant Server database, 3.3% in the ExAC database, and was 4–5% in a large genetic association study.43 The AF in several association studies cited by Gara et al. ranged from 2 to 5%.44, 45 The HABP2 rs7080536 global 1000 Genomes AF is <1%, although there is significant variation across populations. The gene discussed is HABP2; the disease is atrial fibrillation.