These concerns have been exemplified in a recent report by Gara et al. in which rs7080536 in the HABP2 gene was identified as the causative variant in a kindred with familial non-medullary thyroid cancer (FNMTC),7 a disorder for which no causal variants/genes have yet been identified.8 This result was brought into immediate question by several investigators,9–13 with a single positive association14 and a number of other contradictory follow-up studies described below. Here, HABP2 is linked to familial papillary or follicular thyroid carcinoma.