Other hypothetically beneficial characteristics of obesity include a more stable hemodynamic status with mitigation of stress responses and heightened sympathetic and renin–angiotensin activity [72]; increased production of adiponectines [73] and soluble TNF-α receptors [74] by adipose tissue neutralizing the adverse effects of TNF-α; enhanced binding of circulating endotoxins [75] by the characteristically higher cholesterol levels seen in obesity; and sequestration of uremic toxins by adipose tissue [76]. The gene discussed is REN; the disease is obesity due to melanocortin 4 receptor deficiency.