The rs58542926 (A- > G) E167K polymorphism in TM6SF2 is associated with increased steatosis in persons with chronic HCV infection [46], albeit to a lesser extent than the PNPLA3 polymorphism [47], and increased hepatic steatosis, steatohepatitis, and fibrosis in NAFLD [46, 48]. The gene discussed is PNPLA3; the disease is fatty liver disease.