Finally, in a prospective epidemiological study from the EPIC-InterAct cohort, including 8086 incident T2D cases in 11,035 participants over 12.5 years, habitual coffee consumption was associated with a 7% T2D risk reduction among carriers of the diabetes increasing risk allele at transcription factor 7-like 2 locus (TCF7L2) [76]. Here, TCF7L2 is linked to diabetes mellitus.