Our novel finding is that CAPE ameliorates in part ischemia (20 min)-induced renal mitochondrial injury in rats, improves oxidative phosphorylation with complex I-dependent substrate glutamate/malate, increases Ca2+ uptake by mitochondria, partially blocks ischemia-induced caspase-3 activation, and protects kidney cells from ischemia-induced necrosis. Here, CASP3 is linked to ischemia.