There was no protective effect on the mitochondrial outer membrane after pretreatment with CAPE, as the state 3 respiration rate in the presence of cytochrome c (V3 + cyt c), Figures 1 and 2, and cytochrome c effect (V3 + cyt c/V3 ratio, Figure 3) remained similar with both substrates as compared to ischemia group. The gene discussed is CYCS; the disease is ischemia.