A similar correlation between LDs, CD133, and Wnt/β-catenin has been proved in human metastatic melanoma cells, where the downregulation of CD133 resulted in reduced Wnt/β-catenin pathway signaling and decreased levels of LDs, as observed by Raman microspectroscopy, with a consequent reduced metastatic potential [193, 194]. The gene discussed is PROM1; the disease is metastatic melanoma.