Indeed, disruption of the CXCR4–CXCL12 interaction using the CXCR4 antagonist T140 resulted in decreased osteoclast recruitment and lower migration of osteoclast precursors, thus reducing bone resorption in a mouse model of multiple myeloma-mediated focal osteolysis (11). This evidence concerns the gene CXCR4 and plasma cell myeloma.