HMOX1 and diabetic retinopathy: Over-expression or pharmacological induction of HO-1 is neuroprotective in numerous models of CNS injury (Schipper et al., 2009; Jazwa and Cuadrado, 2010), including retinal ischemia-reperfusion (Peng et al., 2008; Sun et al., 2010), optic nerve crush (Himori et al., 2014), and diabetic retinopathy (Fan et al., 2012).