CRH and Anxiety: Increased anxiety-like behavior observed during withdrawal is mediated by the CRF-CRF1 system in the CeA (Cottone et al., 2009a; Iemolo et al., 2013), and renewed consumption of the palatable diet reverses both the withdrawal-dependent behaviors and the heightened CRF expression levels (Teegarden and Bale, 2007; Cottone et al., 2009a; Iemolo et al., 2013).