TLRs play an important role in the pathophysiology of infectious diseases, inflammatory diseases, and possibly in autoimmune diseases.Errfi1 (also known as Mig6) was another dysregulated gene, which is an immediate early gene transcriptionally induced by a divergent array of extracellular stimuli and has a possible role in the response to persistent stress32. Here, ERRFI1 is linked to autoimmune disease.