The 5-HT2 receptor family comprises three closely related receptor subtypes8, 9, namely 5-HT2A, 5-HT2B, and 5-HT2C, that are the molecular targets of prominent drugs acting in different therapeutic areas1–4, 9–11 (e.g., schizophrenia, depression, hypertension, anxiety). The gene discussed is HTR2A; the disease is major depressive disorder.