In the univariate analysis, variables associated with shorter survival were older age, ASA physical status >3, lower body weight, comorbidities (diabetes, ischemic heart disease, heart failure, old stroke, and chronic kidney disease), higher pretreatment CEA level, longer anesthesia time, perioperative pRBC transfusion, advanced cancer stage, specific pathologic findings (poor differentiation, mucinous and signet-ring histology, lymphovascular invasion, and perineural invasion) and postoperative radiotherapy (Table 2). Here, CEACAM5 is linked to chronic kidney disease.