Univariate analysis revealed several significant risk factors of cancer recurrence (Table 2), including chronic kidney disease, higher pretreatment CEA level, longer anesthesia time, perioperative pRBC transfusion, advanced cancer stage, specific pathologic findings (poor differentiation, signet-ring histology, lymphovascular invasion, and perineural invasion), preoperative chemotherapy and/or radiotherapy, and postoperative chemotherapy or radiotherapy. Here, CEACAM5 is linked to chronic kidney disease.