F10 and autoimmune polyendocrinopathy: We have shown that FXa stimulation of HUVEC is mediated via PAR-1 and PAR-2 dependent signalling and that this response is enhanced by IgG from FXa reactive antibody positive patients with APS as well as SLE/APS- and can be blocked by a specific FXa proteolytic inhibitor, antistasin, HCQ and fluvastatin.