Of these 5 patients: none were positive for anti-β2GPI antibodies; three had single LA positivity; one had weak non-persistent aCL positivity; one with strong persistent LA positivity had strong persistent IgM aCL positivity; and none have developed any manifestations of APS despite a disease duration ranging from 11–20 years in these five patients alone. This evidence concerns the gene ACLY and autoimmune polyendocrinopathy.