Differences in brain vasculature, however, are unlikely to underlie the protection from stroke in tau−/− mice, since laser Doppler flowmetry showed the same reduction in cerebral blood flow during the MCAO procedure in tau+/+ and tau−/− mice, and reduction of SynGAP1 levels restored susceptibility to brain damage after MCAO in tau−/− mice. Here, SYNGAP1 is linked to stroke disorder.