In the present study, we examined the mRNA levels of glycosyltransferases, including FUT1, FUT2, B3GALT5 and ST3GAL2, responsible for the synthesis of Globo H, SSEA-3 and SSEA-4 in 135 HCC specimens by qRT-PCR and correlated with clinical-pathological parameters and outcomes of patients. The gene discussed is ST3GAL2; the disease is hepatocellular carcinoma.