RXFP1 and Hepatic fibrosis: We investigate generation of additional RXFP1 agonists through a cAMP-mediated assay; although high-throughput screening afforded no further specific agonists, we describe the identification of novel, ML290-related activators of RXFP1-mediated cAMP and their use, together with H2-RLX and ML290 in understanding pathways relevant to liver fibrosis, primarily in the hHSC line LX-2.