CCN2 and fibrosis: As regarding markers of fibrosis (TGF-β, CTGF, and collagen-I), there was a statistical significant decrease in neupogen treated group and MSCs treated groups (P-value <0.05) with greater significant decrease observed in MSCs and neupogen treated group compared with fibrosis group (P=0.000) (Figures 3F,4,5 matched with Table 3, respectively).