To investigate the role of NFκB in sarcoma, we first conducted a targeted chemical screen on 28 biologically independent mouse, canine and human cell lines and primary cell cultures, including aRMS, eRMS, undifferentiated pleomorphic sarcoma (UPS) and epithelioid sarcoma (EPS) (Table 1). The gene discussed is NFKB1; the disease is epithelioid sarcoma.