Since the discovery that PINK1/Parkin pathway can regulate mitochondrial clearance (Yang et al., 2006; Narendra et al., 2008), more proteins associated to PD have been linked to the control of mitochondrial dynamics (Xiong et al., 2009; Ziviani et al., 2010; Wang et al., 2012, 2016; Pryde et al., 2016). Here, PRKN is linked to Parkinson disease.