In xenograft and allograft models of prostate cancer, chemokine (C-X-C motif) ligand 16 (CXCL16)/CXC receptor 6 (CXCR6) chemokine signaling promotes recruitment of bone marrow-derived MSCs and their differentiation into CAFs, which in turn promote prostate tumor cell invasion and metastasis through production of chemokines such as CXCL12 (Jung et al., 2013; Mognetti et al., 2013) and chemokine (C-C motif) ligand 5 (CCL5) (Luo et al., 2015). The gene discussed is CCL5; the disease is prostate cancer.