CPVT1 is the most common type of CPVT and is caused by autosomal dominant mutations in the cardiac ryanodine receptor type 2 gene (RYR2), a mediator of calcium release in the sarcoplasmic reticulum (SR) (Priori and Chen, 2011). The gene discussed is RYR2; the disease is catecholaminergic polymorphic ventricular tachycardia.