ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive: Ponatinib (Iclusig) is an orally available pan-BCR-ABL tyrosine kinase inhibitor that has been approved for treatment of resistant chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Zhou et al., 2011; Cortes et al., 2012; Razzak, 2013; Miller et al., 2014).