HSPG2 and viral infectious disease: Since PLC signaling inhibitor apparently affected BoHV-1 replication in both MDBK and RS-1 cells, we further examined whether BoHV-1 infection affected PLC signaling by testing the kinetics of phosphorylated PLCγ-1(Ser1248) during virus infection of MDBK cells as previously described [18, 21].