IGF1 and urinary bladder neoplasm: To identify predictor of IGF pathway activation within IGF member genes, we then evaluated the Spearman correlation between the phosphorylated-INSR/IGFR RPPA signal and the mRNA levels for IGF pathway genes (the Affymetrix Human Exon1.0 ST array signal) for these 97 bladder tumors from the FBLAD-Exon tumor set (Fig. 3b).