Recently, the Translational Research Investigating Biomarker Endpoints in AKI (TRIBE-AKI) Consortium has shown that among patients with clinical AKI following major cardiac surgery [4], the highest compared to the lowest tertiles of urine neutrophil gelatinase-associated lipocalin (NGAL), IL-18 and KIM-1 were each independently associated with a more than doubling of mortality risk after hospital discharge [5]. The gene discussed is HAVCR1; the disease is acute kidney injury.