Another vascular disrupting agent aflibercept was a recombinant human fusion protein targeting the VEGF pathway, did not improve OS (10.1 months for aflibercept and 10.4 for placebo; p = 0.9) when it was added to second-line docetaxel chemotherapy in advanced or metastatic NSCLC, although PFS was different between the combination group (5.2 months) and chemotherapy group (4.1 months; p = 0.0035) [46]. The gene discussed is VEGFA; the disease is non-small cell lung carcinoma.