EGFR and non-small cell lung carcinoma: Another phase II trial demonstrated that adding sorafinib to EGFR-TKIs did not significantly enhance PFS (3.38 months with combination therapy, and 1.94 months with erlotinib alone) and OS (7.62 months with combination therapy, and 7.23 months with erlotinib alone) in unselected advanced NSCLC who progressed following first-line chemotherapy [84].