In this review, we will summarize the current state and recent advances in the clinical treatment of advanced NSCLC with angiogenesis inhibitors, including the combination of antiangiogenic therapy and chemotherapy (Table 1 and 2), the combination of antiangiogenic therapy and EGFR TKIs (Table 3) or immune checkpoint inhibitors (Table 4), and the use of antiangiogenic agents alone (Table 5). Here, EGFR is linked to non-small cell lung carcinoma.