SDHB and cancer: Mutations in SDH have been identified in specific cancers, both genetic and sporadic, such as familial paraganglioma/pheochromocytoma (PGL/PCC), renal carcinoma [4], thyroid cancer [5], ovarian cancer [6], neuroblastoma [7], gastrointestinal stromal tumor [8, 9], and even testicular seminoma [10].