miR-122 were down-regulated in the asthenozoospermia, which is synthesized only in round spermatids, participating in the post-transcriptional down-regulation of the TNP2 through targeting the 3′ untranslated region of the TNP2 mRNA; a decreased expression of HOTAIR, one of lncRNAs, may reduce H4 acetylation in Nrf2 promoter and Nrf2 expression. The gene discussed is HOTAIR; the disease is Reduced sperm motility.