In human patients with schizophrenia, DARPP-32 was significantly decreased in the dorsolateral prefrontal cortex circuit (DLPFC) [32], A postmortem study showed a significant decrease of DARPP-32 in the DLPFC of patients with schizophrenia, and the decrease of DARPP-32 was associated with dysfunction of dopaminergic neurons [70, 71]. The gene discussed is PPP1R1B; the disease is schizophrenia.