We searched for relevant studies concerning biomarkers in mesothelioma through MEDLINE (PubMed Database) and Web of Science using the following keywords and their combinations: “mesothelioma”, “biomarker”, “diagnosis”, “tumor marker”, “mesothelin”, “fibulin-3”, “osteopontin”, “megakaryocyte potentiating factor”, “galectin-3”, “thioredoxin” and “HMGB-1”, “RNA”, “lung cancer”, “volatile organic compounds”, “electronic nose”, “ion mobility spectrometry”, “GC-MS”, “headspace”, “cell line”, “asbestos”, “exhaled breath”, “breath analysis” and “metabolomics”. Here, SPP1 is linked to mesothelioma.