Such as Vidyanani et al reported that VitD3 could suppress IFN-γ and IL-12 in peripheral leukocytes from patients with Mycobacteria tuberculosis [30], while Di Filippo et al observed that administration with VitD supplements suppressed both IL-4 and IFN-γ in the serum of patients with atopic dermatitis [31]. This evidence concerns the gene IFNG and atopic eczema.