The recent studies showed that both AZD9291 and CO-1686 exhibited excellent clinical efficacy in NSCLC patients harboring EGFR T790M, with more than 50% response rates, meanwhile skin and gastrointestinal toxicities are also less than those typically observed for the first generation EGFR TKIs [16–18]. Here, EGFR is linked to non-small cell lung carcinoma.