CDH2 and ovarian cancer: In 20(S)-Rg3-treated SKOV3 and 3AO cells, epithelial marker E-cadherin was up-regulated, while mesenchymal markers N-cadherin and vimentin were down-regulated (Figure 1A), indicating that 20(S)-Rg3 reversed EMT in SKOV3 and 3AO ovarian cancer cells.