Here, we report the frequency of ROS1 and RET rearrangements in a large cohort of 713 Caucasian patients with non-squamous NSCLC lacking EGFR/KRAS/BRAF/HER2/PI3KCA/ALK alterations by using fluorescence in situ hybridization (FISH). This evidence concerns the gene KRAS and non-small cell lung carcinoma.