Some researchers have transduced several transcription factors such as octamer-binding transcription factor 4 (OCT4), sex determining region Y-box 2 (SOX2), and kruppel-like factor 4 (KLF4) into tumor cells, which can enhance certain cell-stemness properties including self-renewal and chemo-resistance [14–17]. This evidence concerns the gene POU5F1 and neoplasm.