In CWR22Rv1 cell xenograft tumor models of nude mice, over-expression of CXCL13 in CWR22Rv1 cells (stable-expression cells) enhanced tumor growth a little bit and knock-down of CXCL13 by shCXCL13 (shRNA of CXCL13, stable cells) obviously inhibited tumor growth in vivo by compared to control group (stable cells with pcDNA3.1(+) and control shRNA), while no changes was observed in the mice body-weight (Figure 8B-8D). Here, CXCL13 is linked to neoplasm.