Additionally, the difference of CXCL13 expression among androgen-dependent PCa cells, androgen-independent PCa cells and normal prostate cells (Figure 1D and 1E) indicates that CXCL13 expression is not only regulated by androgen/AR axis, but may be also regulated by other different transcription factors via androgen-independent signal pathways. This evidence concerns the gene AR and posterior cortical atrophy.