Additionally, the difference of CXCL13 expression among androgen-dependent PCa cells, androgen-independent PCa cells and normal prostate cells (Figure 1D and 1E) indicates that CXCL13 expression is not only regulated by androgen/AR axis, but may be also regulated by other different transcription factors via androgen-independent signal pathways. The gene discussed is CXCL13; the disease is posterior cortical atrophy.