lncRNAs can recruit chromatin-modifying enzymes to target genes and regulate their transcription either in cis or in trans. For example, lncRNA AGAP2-AS1 represses LATS2 and KLF2 expression through interacting with EZH2 and LSD1 in non-small-cell lung cancer cells [29]. This evidence concerns the gene KLF2 and non-small cell lung carcinoma.