TGFB1 and pulmonary arterial hypertension: ZBTB18 (also known as TAZ1 or RP58) has never been implicated in PAH, but its role in mitochondria [19] and as a transcriptional repressor regulating ID family genes, important downstream targets of BMP/ TGFb signalling [20] may be relevant in the disease pathophysiology [21–23].