In a multivariate cox proportional hazards model, high expression of PD-L1 prevailed to be an independent and in fact the strongest prognostic factor of patient's outcome, even when verified together with recognized prognostic factors like tumor size, lymph node involvement, distant metastases, surgical margin status, lymphatic invasion, vascular invasion, grading, and extracapsular expansion (p=0.02; HR=2.926 [95%CI=1.183 – 7.235]; Table 3). The gene discussed is CD274; the disease is neoplasm.