The results indicated that the 10 μg dose of GPC3/CD3 BiTE could potently suppress the outgrowth of SK-Hep-1-GPC3 tumor xenografts in vivo (Figure 6A), while both 1 μg and 10 μg doses of GPC3/CD3 BiTE had no effect on the outgrowth of SK-Hep-1 tumor xenografts (Figure 6B). This evidence concerns the gene GPC3 and neoplasm.