NANOGP8 and medical procedure: Despite the solid evidence that NanogP8 promotes the defined characteristics of CSCs [9, 35–37] and functions as an oncogenic factor in vitro, it remains unclear whether NanogP8 might exhibit pro-tumorigenic activities in vivo, and, in particular, whether tissue-specific overexpression of NanogP8 is sufficient to promotes prostate tumorigenesis.