MYC and prostate intraepithelial neoplasia: Myc is overexpressed in >80% human PCa due to genomic amplification and post-transcriptional mechanisms [59–61] and forced expression of Myc in mouse prostates in Hi-Myc transgenic mice reliably leads to the development of murine PIN that progresses to invasive adenocarcinomas at 3 - 6 months age [51].