After eliminating polymorphic loci represented in less than two articles, 15 SNPs were found to be significantly associated with the risk of NPC: TP53 (rs1042522, C>G) [14–18], GSTM1 (+/DEL) [19–21], IL-10 (rs1800896, A>G) [22, 23], GABBR1 (rs2076483, T>C; rs29232, G>A) [24, 25], MDM2 (rs2279744, T>G) [16, 26], miR-146a (rs2910164, C>G) [27, 28], MDS1-EVI1 (rs6774494, G>A) [29, 30], XPC (rs2228000, C>T) [30, 31],, HCG9 (rs3869062, A>G; rs16896923, T>C) [24, 25], HLA-F (rs3129055, T>C) [24, 25], MMP2 (rs243865, C>T) [32, 33], SPLUNC1 (rs2752903, T>C; rs750064, A>G) [34, 35]. This evidence concerns the gene MDM2 and nasopharyngeal carcinoma.