In esophageal squamous cell carcinoma, Flotillin-1 facilitated recruitment of the tumor necrosis factor-α receptor to lipid rafts; promoted K63-linked polyubiquitination of the signaling intermediaries tumor necrosis factor receptor associated factor 2, receptor interacting protein and NEMO; and sustained the activation of NF-κB. The gene discussed is FLOT1; the disease is esophageal squamous cell carcinoma.