Meta-analysis indicated that Flotillin-1 expression level was related to histological grade(OR =2.22; 95% CI: 1.04-4.78, p=0.04) and depth of primary tumor invasion(OR =2.73; 95% CI: 1.44-5.17, p=0.002) (Table 3, All those figures was presented in Supplementary Information). The gene discussed is FLOT1; the disease is neoplasm.