Additionally, high expressionlevelof Flotillin-1 was also found to be significantly associated with lymph node metastasis (OR =6.30; 95% CI:3.15-12.59, p<0.001), distant metastasis (OR =6.02; 95% CI: 1.50-24.06, p=0.01) and more advanced TNM stage (OR =4.69; 95% CI: 2.74-8.03, p<0.001). This evidence concerns the gene FLOT1 and metastatic malignant neoplasm in the lymph nodes.