HIF1A and familial pancreatic carcinoma: Recently, the development of pancreatic cancer has been attributable to the overexpression of several oncogenes such as KRAS [12], HIF-1α [13], MYB [14], SOX9 [15] and VEGF [16], inactivation tumor suppressor genes such as TP53 [17], or the deregulation of various signaling pathway (Hedgehog [18] and PI3K/Akt [19]).