Because two matrix metalloproteinases (MMPs), MMP-2 and MMP-9, are overexpressed in many types of cancers and play key roles in tumor metastasis [36, 37], and IL-8 is able to induce MMP-2 and MMP-9 production [28], we wanted to examine if CRABP-II enhances cell migration and invasion through IL-8 mediated MMP-2 and MMP-9 induction. Here, MMP2 is linked to neoplasm.