Since our current studies have shown strong effects of gal/analogs on the Mnk1/2-eIF4E axis and the latter is implicated in oncogenesis and gemcitabine resistance in pancreatic cancer [30], we hypothesize that gal/analogs’ effects on Mnk1/2 could greatly influence their activity in PDAC cells lines and xenograft tumors. The gene discussed is EIF4E; the disease is familial pancreatic carcinoma.