TERT and hepatocellular carcinoma: In HCC, SIRT1 is aberrantly overexpressed and activates TERT gene promoter [10], YAP/TEAD4 association [11], c-Myc stabilization [12], NF-kB [26], wnt/β-catenin [13], and PI3K/AKT [27] signaling to stimulate cell proliferation and metastasis [7, 28, 29].