Higher expression of SIRT1 was associated with larger tumor size (OR=1.81, 95%CI: 1.05-3.13, P=0.03) (Supplementary Figure S4), and with increased expression of p53 (OR=2.71, 95%CI: 1.39-5.29, P=0.003) (Supplementary Figure S5). This evidence concerns the gene TP53 and neoplasm.