We compared the effect of IGF-I depletion in 2 models; one of an acute IGF-I deficiency that was induced 2 days prior to tumor cell injection (iLID2D) and the other of a more sustained IGF-I deficiency induced 3 weeks prior to analysis (iLID3W). Here, IGF1 is linked to hyperinsulinemic hypoglycemia, familial, 4.