IGF1 and neoplasm: Activated HSC release various growth factors such as epidermal growth factor (EGF), vascular endothelial growth factor (VEGF), and insulin-like growth factor-I (IGF-I) and metalloproteinases (MMP-2,-9,-13) [3] that together contribute to recruitment of endothelial cells and angiogenesis and promote tumor cell invasion and proliferation [10].