Indeed, adding soluble CXCL12, BAFF or APRIL to purified CLL cells cultures or blocking peptides of BAFF and APRIL to CLL cells/NLC cocultures was shown to only partly increase CLL cell viability compared to that resulting from co-culture with NLC [8, 23]. The gene discussed is CXCL12; the disease is B-cell chronic lymphocytic leukemia.